Other Names RYR-2, cardiac muscle ryanodine receptor-calcium release channel, cardiac muscle-type ryanodine receptor, ryanodine receptor 2
All Sites Human: Ser2808; Mouse: Ser2808
Storage/Stability Store at -20℃/1 year
Form Or Antibody
Form of Antibody Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human RyR2 around the phosphorylation site of serine 2808 (R-I-SP-Q-T).
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Specificty Sensitivity
Specificity/Sensitivity RyR2 (Phospho-Ser2808) antibody detects endogenous levels of RyR2 only when phosphorylated at serine 2808.
ReferencesDawei Jiang, Circ. Res., Nov 2005; 97: 1173 - 1181.
Guojin Huang, J. Biol. Chem., May 2007; 282: 14283 - 14290.
James D. Johnson, J. Biol. Chem., Jun 2004; 279: 24794 - 24802.
Guangju Ji, J. Gen. Physiol., Mar 2004; 123: 377 - 386.