Other Names PLN, PPLA, PPLA_DOG, cardiac phospholamban, phospholamban
All Sites Human: Ser16+Thr17; Mouse: Ser16+Thr17; Rat: Ser16+Thr17
Storage/Stability Store at -20℃/1 year
Form Or Antibody
Form of Antibody Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human PLB around the phosphorylation site of serine 16 and threonine 17 (R-A-SP-TP-I-E).
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Specificty Sensitivity
Specificity/Sensitivity PLB (Phospho-Ser16+Thr17) antibody detects endogenous levels of PLB only when phosphorylated at serine 16 and threonine 17.
ReferencesFujii J., J. Biol. Chem. 266:11669-11675(1991).
McTiernan C.F., J. Mol. Cell. Cardiol. 31:679-692(1999).
Haghighi K., Proc. Natl. Acad. Sci. U.S.A. 103:1388-1393(2006).
Research AreaAutophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells