Other Names EC 6.3.2.-, PARK2, PRKN, PRKN2, Parkinson disease protein 2, Parkinson juvenile disease protein 2, ubiquitin E3 ligase PRKN
All Sites Human: Ser131; Mouse: Ser131
Storage/Stability Store at -20℃/1 year
Form Or Antibody
Form of Antibody Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Parkin around the phosphorylation site of serine 131 (K-D-SP-P-P).
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Specificty Sensitivity
Specificity/Sensitivity Parkin (Phospho-Ser131) antibody detects endogenous levels of Parkin only when phosphorylated at serine 131.
ReferencesJ. Menéndez, Hum. Mol. Genet., Jul 2006; 15: 2045 - 2058.
Miratul M.K. Muqit, Hum. Mol. Genet., Jan 2004; 13: 117 - 135.
Kenny K. K. Chung, Sci. Aging Knowl. Environ., Apr 2004; 2004: or11.
Se Jung Kim, J. Biol. Chem., Oct 2003; 278: 41890 - 41899.