Other Names EC 2.7.11.1, KS6B1, P70-S6K, RPS6KB1, Ribosomal protein S6 kinase, Ribosomal protein S6 kinase, 70kDa, polypeptide 1, S6K, kinase p70S6K, p70-S6K
All Sites Human: Ser418; Mouse: Ser441; Rat: Ser418
Storage/Stability Store at -20℃/1 year
Form Or Antibody
Form of Antibody Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human P70S6K around the phosphorylation site of serine 418 (I-G-SP-P-R).
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Specificty Sensitivity
Specificity/Sensitivity p70 S6 Kinase (Phospho-Ser418) antibody detects endogenous levels of P70S6K only when phosphorylated at serine 418.
ReferencesO. Jameel Shah, J. Biol. Chem., Jan 2002; 277: 2525 - 2533.
Chuanshu Huang, Cancer Res., Oct 2002; 62: 5689 - 5697.
Isabelle Briaud, Diabetes, Apr 2003; 52: 974.
Research AreaAutophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells