Other Names CD220 antigen, EC 2.7.10.1, IR, insulin receptor, kinase InsR
All Sites Human: Tyr1361; Mouse: Tyr1351; Rat: Tyr1362
Storage/Stability Store at -20℃/1 year
Form Or Antibody
Form of Antibody Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human IR around the phosphorylation site of tyrosine 1361 (I-P-YP-T-H).
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Specificty Sensitivity
Specificity/Sensitivity IR (Phospho-Tyr1361) antibody detects endogenous levels of IR only when phosphorylated at tyrosine 1361.
ReferencesLaura Sciacca, Endocrinology, Jun 2003; 144: 2650.
Mark Westcott, Asia Pacific Journal of Human Resources, Aug 2003; 41: 172 - 189.
Adam Denley, Mol. Endocrinol., Oct 2004; 18: 2502 - 2512.
Rita Slaaby, J. Biol. Chem., Sep 2006; 281: 25869 - 25874.