Other Names CREB-1, CREB1, cAMP-response element binding protein
All Sites Human: Ser121; Mouse: Ser121; Rat: Ser121
Storage/Stability Store at -20℃/1 year
Form Or Antibody
Form of Antibody Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human CREB around the phosphorylation site of serine121 (T-D-SP-Q-K).
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Specificty Sensitivity
Specificity/Sensitivity CREB (Phospho-Ser121) antibody detects endogenous levels of CREB only when phosphorylated at serine 121.
ReferencesLionel Groussin, J. Clin. Endocrinol. Metab., Jan 2000; 85: 345 - 354.
Deepa B. Shankar, Blood (ASH Annual Meeting Abstracts), Nov 2005; 106: 367.
LA Berkowitz and MZ Gilman, PNAS, Jul 1990; 87: 5258.
Michelle L. Kingsley-Kallesen, J. Biol. Chem., Nov 1999; 274: 34020.