Other Names AIK, ARK1, AYK1, Aurora-A, Aurora-family kinase 1, Aurora-related kinase 1, Aurora/IPL1-related kinase 1, BTAK, Breast-tumor-amplified kinase, EC 2.7.11.1, IAK1, Ipl1- and aurora-related kinase 1, STK15, STK6, Serine/threonine kinase 15, Serine/threonine kinase 6, Serine/threonine kinase Ayk1, kinase AurA
All Sites Human: Thr288; Mouse: Thr279; Rat: Thr281
Storage/Stability Store at -20℃/1 year
Form Or Antibody
Form of Antibody Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Aurora Kinase around the phosphorylation site of threonine 288 (R-T-TP-L-C).
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Specificty Sensitivity
Specificity/Sensitivity Aurora Kinase (Phospho-Thr288) antibody detects endogenous levels of Aurora Kinase only when phosphorylated at threonine 288.
ReferencesAmy E. Geddis, Blood, Aug 2004; 104: 1017 - 1024.
Edmund Chun Yu Lee, Cancer Res., May 2006; 66: 4996 - 5002.
Kaori Sasai, AACR Meeting Abstracts, Apr 2005; 2005: 608.
T Marumoto, Genes Cells, Nov 2002; 7: 1173 - 1182.