All Names
AlternameIRS-1, IRS1, Insulin receptor substrate-1
All SitesHuman: Ser1101; Mouse: Ser1097; Rat: Ser1100
Form Or Antibody
Form of AntibodyRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage/StabilityStore at -20℃/1 year
ImmunogenThe antiserum was produced against synthesized phosphopeptide derived from human IRS-1 around the phosphorylation site of serine 1101 (H-S-SP-E-T).
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Specificty Sensitivity
Specificity/SensitivityIRS-1 (Phospho-Ser1101) antibody detects endogenous levels of IRS-1 only when phosphorylated at serine 1101.
ReferencesXJ Sun, J. Biol. Chem., Nov 1992; 267: 22662 - 22672.
Laurent Delahaye, Endocrinology, Dec 1998; 139: 4911.
Angela M. Valverde, Mol. Cell. Biol., Apr 2001; 21: 2269 - 2280.
Xiao Jian Sun, J. Biol. Chem., May 1996; 271: 10583.
Research AreaAutophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells