All Names
AlternameBCAR1, Breast cancer anti-estrogen resistance 1, CRK-ASSOCIATED SUBSTRATE, CRKAS
All SitesHuman: Tyr410; Mouse: Tyr414; Rat: Tyr508
Form Or Antibody
Form of AntibodyRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage/StabilityStore at -20℃/1 year
ImmunogenThe antiserum was produced against synthesized phosphopeptide derived from human p130 Cas around the phosphorylation site of tyrosine 410 (G-V-YP-A-V).
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Specificty Sensitivity
Specificity/Sensitivityp130 Cas (Phospho-Tyr410) antibody detects endogenous levels of p130 Cas only when phosphorylated at tyrosine 410.
ReferencesKatarzyna Modzelewska, J. Biol. Chem., Dec 2006; 281: 37527 - 37535.
Kevin Ogden, Am J Physiol Heart Circ Physiol, Dec 2006; 291: H2857 - H2863.
Sangkil Nam, Cancer Res., Oct 2005; 65: 9185 - 9189.
Norikazu Yamana, Mol. Cell. Biol., Sep 2006; 26: 6844 - 6858.