All Names
AlternameC-COT, COT proto-oncogene serine/threonine-protein kinase, Cancer Osaka thyroid oncogene, EC 2.7.11.25, M3K8, MAP3K8, Mitogen-activated protein kinase kinase kinase 8, TPL-2, TPL2, Tpl2, Tumor progression locus 2, kinase Cot
Form Or Antibody
Form of AntibodyRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage/StabilityStore at -20℃/1 year
ImmunogenThe antiserum was produced against synthesized non-phosphopeptide derived from human COT around the phosphorylation site of threonine 290 (R-G-TP-E-I).
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificty Sensitivity
Specificity/SensitivityCOT (Ab-290) antibody detects endogenous levels of total COT protein.
ReferencesLawrence P. Kane, Mol. Cell. Biol., Aug 2002; 22: 5962 - 5974.
Brenda S. Luciano, J. Biol. Chem., Dec 2004; 279: 52117 - 52123.
Matilde Caivano, J. Biol. Chem., Dec 2003; 278: 52124 - 52130.
Kenji Sugimoto, J. Clin. Invest., Sep 2004; 114: 857 - 866.