All Names
AlternameEC 3.1.3.48, PTN11, PTP-1D, PTP-2C, PTP2C, PTPN11, Protein-tyrosine phosphatase 2C, Protein-tyrosine phosphatase, non-receptor type 11, SH-PTP2, SH-PTP3, SHPTP2
All SitesHuman: Tyr580; Mouse: Tyr584; Rat: Tyr580
Form Or Antibody
Form of AntibodyRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage/StabilityStore at -20℃/1 year
ImmunogenThe antiserum was produced against synthesized phosphopeptide derived from human SHP-2 around the phosphorylation site of tyrosine 580 (R-V-YP-E-N).
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Specificty Sensitivity
Specificity/SensitivitySHP-2(phospho-Tyr580) antibody detects endogenous levels of SHP-2 only when phosphorylated at tyrosine 580.
ReferencesMinako Yamaoka-Tojo, Arterioscler. Thromb. Vasc. Biol., Sep 2006; 26: 1991 - 1997.
Liang Liang, Endocrinology, Sep 2000; 141: 3328.
Tony Avril, J. Immunol., Dec 2004; 173: 6841 - 6849.
Laura A. Maile, Mol. Biol. Cell, Sep 2003; 14: 3519.