All Names
AlternameA4, ABPP, AD1, APP, APPI, Alzheimer's disease amyloid protein, Amyloid beta A4 protein precursor, Beta-amyloid protein 40, Beta-amyloid protein 42, C31, C83, CVAP, Cerebral vascular amyloid peptide, Gamma-CTF(50), Gamma-CTF(57), Gamma-CTF(59), P3(40), P3(42), PN-II, PreA4, Protease nexin-II, Soluble APP-alpha (S-APP- alpha), Soluble APP-beta (S-APP-beta)
All SitesHuman: Thr743; Mouse: Thr743; Rat: Thr743
Form Or Antibody
Form of AntibodyRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage/StabilityStore at -20℃/1 year
ImmunogenThe antiserum was produced against synthesized phosphopeptide derived from human Amyloid β A4 around the phosphorylation site of threonine 743 (A-V-TP-P-E).
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Specificty Sensitivity
Specificity/SensitivityAmyloid β A4 (phospho-Thr743/668) antibody detects endogenous levels of Amyloid β A4 only when phosphorylated at threonine 743.
ReferencesMing-Sum Lee J. Cell Biol., Oct 2003; 163: 83.
Tadashi Nakaya and Toshiharu Suzuki Genes Cells, Jun 2006; 11: 633 - 645
Keun-A Chang, Mol. Cell. Biol., Jun 2006; 26: 4327 – 4338.
Thor D. Stein J. Neurosci., Sep 2004; 24: 7707 - 7717.
Research AreaAutophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells