BackgroundThe protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination.
Product Information
Clone Number5C5
SpeciesMouse IgG1
Entrez Gene7520
Recommended DilutionsWB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF:1/200 - 1/1000, FC:1/200 - 1/400,
ELISA: Propose dilution 1/10000.
Molecular Weight86kDa
All Names
AlternameKU80; KUB2; Ku86; NFIV; KARP1; KARP-1
ImmunogenPurified recombinant fragment of human XRCC5 expressed in E. Coli.
Storage/StabilityStore at 4℃, for long term storage, store at -20℃.
Form Or Antibody
Form of AntibodyAscitic fluid containing 0.03% sodium azide.
Research AreaAutophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells