p63α Antibody

Name: p63α Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E10-30176
Price: 225 USD
Availability: InStock

E10-30176Cite ID: EN0013854Datasheet COA MSDS

ReactivityHuman; Mouse; Rat; Monkey

ApplicationsWB, IHC, ELISA. Not yet tested in other applications.

$225/ 100μg/100μl

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (3)Documents

BackgroundThe p63 gene is a homologue of the p53 tumor suppressor gene. Like p53, p63 contains a transactivation (TA) domain induce the transcription of target genes, a DNA binding domain, and an oligomerization domain (OD), used to form tetramers. In contrast to p53, the p63 gene encodes for at least six major isotypes. Three isotypes (TAp63α, TAp63β, and TAp63γ) contain the transactivating (TA) domain and are able to transactivate p53 report genes and induce apoptosis. In contrast, the other three isotypes (ΔNp63α, ΔNp63β, ΔNp63γ) are transcribed from an internal promoter localized within intron3, lack the TA domain, and act as dominant-negatives to suppress transactivation by both p53 and TAp63 isotypes. p63 is highly expressed in the basal cells of the epithelium significant for proper limb outgrowth and morphogenesis.4 In differentiating tissues, p63 is crucial for maintaining the stem cell identity of the basal cells, and is indispensable for correct development of the skin as well as the limb. p63-deficient mice lack all squamous epithelia and their derivatives, including hair, whiskers, teeth, as well as mammary, lacrimal, and salivary glands.Tissue specificity: Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type.

Product Information

Clone Number4E5

SpeciesMouse IgG1

Entrez Gene8626

Recommended DilutionsWB: 1/500 - 1/2000, IHC: 1/200-1/1000 , ELISA: Propose dilution 1/10000.

Molecular Weight51kDa

All Names

AlternameP51B; KET; p63α

ImmunogenSynthesized peptide of human p63α.

Storage/StabilityStore at 4℃, for long term storage, store at -20℃.

Form Or Antibody

Form of AntibodyAscitic fluid containing 0.03% sodium azide.

Price225$

Research AreaAutophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells

Figure 1: Western blot analysis and lung cancer using p63α mouse mAb against A431 (1), Hela (2), Jurkat (3), THP-1 (4), NIH/3T3 (5), Cos7 (6) and PC-12 (7) cell lysate.

Immunohistochemical analysis of paraffin-embedded ovarian cancer (left) (right) using p63α mouse mAb with DAB staining.

Immunohistochemical analysis of paraffin-embedded ovarian cancer (right) using p63α mouse mAb with DAB staining.

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E10-30176-Conjugate. Price: $485 / Size: 100μl.

E10-30176-FITC$485 / 100μlE10-30176-Biotin$485 / 100μlE10-30176-HRP$485 / 100μlE10-30176-AP$485 / 100μlE10-30176-AF350$485 / 100μlE10-30176-AF405M$485 / 100μlE10-30176-AF488$485 / 100μlE10-30176-AF514$485 / 100μlE10-30176-AF532$485 / 100μlE10-30176-AF555$485 / 100μlE10-30176-AF568$485 / 100μlE10-30176-AF405S$485 / 100μlE10-30176-AF405L$485 / 100μlE10-30176-AF546$485 / 100μlE10-30176-AF594$485 / 100μlE10-30176-AF610$485 / 100μlE10-30176-AF635$485 / 100μlE10-30176-AF647$485 / 100μlE10-30176-AF680$485 / 100μlE10-30176-AF700$485 / 100μlE10-30176-AF750$485 / 100μlE10-30176-AF790$485 / 100μlE10-30176-APC$485 / 100μlE10-30176-PE$485 / 100μlE10-30176-Cy3$485 / 100μlE10-30176-Cy5$485 / 100μlE10-30176-Cy5.5$485 / 100μlE10-30176-Cy7$485 / 100μlE10-30176-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.