BackgroundThe protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Tissue specificity: Widely expressed. In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart.
Product Information
Clone Number6E6
SpeciesMouse IgG1
Entrez Gene2908
Recommended DilutionsWB: 1/500 - 1/2000, IHC: 1/200-1/1000, IF:1/200-1/1000, FC: 1/200-1/400,
ELISA: Propose dilution 1/10000.
Molecular Weight86kDa
All Names
AlternameGR; GCR; GRL; GCCR; NR3C1
ImmunogenPurified recombinant fragment of human NR3C1 expressed in E. Coli.
Storage/StabilityStore at 4℃, for long term storage, store at -20℃.
Form Or Antibody
Form of AntibodyAscitic fluid containing 0.03% sodium azide.
Research AreaAutophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells