BackgroundTranscriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. Tissue specificity: Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions.
Product Information
Clone Number6E4
SpeciesMouse IgG1
Entrez Gene11168
Recommended DilutionsWB: 1/500 - 1/2000, IHC:1/200-1/1000, IF: 1/200-1/1000,
ELISA: Propose dilution 1/10000.
Molecular Weight75kDa
All Names
Alternamep52; p75; PAIP; DFS70; LEDGF; PSIP2; MGC74712; PSIP1
ImmunogenPurified recombinant fragment 214-332aa of human PSIP1 expressed in E. Coli.
Storage/StabilityStore at 4℃, for long term storage, store at -20℃.
Form Or Antibody
Form of AntibodyAscitic fluid containing 0.03% sodium azide.