BackgroundThe protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.
Product Information
Clone Number3B5
SpeciesMouse IgG1
Entrez Gene23118
Recommended DilutionsWB: 1/500 - 1/2000, FC: 1/200-1/400,
ELISA: Propose dilution 1/10000.
Molecular Weight80kDa
All Names
AlternameCHTD2; FLJ21885; KIAA0733; MAP3K7IP2; TAB2
ImmunogenPurified recombinant fragment of human TAB2 expressed in E. Coli.
Storage/StabilityStore at 4℃, for long term storage, store at -20℃.
Form Or Antibody
Form of AntibodyAscitic fluid containing 0.03% sodium azide.
Research AreaAutophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells