You are here: EnoGene Home > Products > Pathological (Immunohistochemistry, IHC) antibodies > CDH1 Antibody
CDH1 Antibody
Datasheet
Catalog Number:
E10-30121Amount:
100μg/100μlBackground:
E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.Clone Number:
7H12Species:
Mouse IgG1Altername:
UVO; CDHE; ECAD; LCAM; Arc-1; CD324; CDH1Entrez Gene:
999Immunogen:
Purified recombinant fragment of human CDH1 expressed in E. Coli.Storage/Stability:
Store at 4℃, for long term storage, store at -20℃.Form of Antibody:
Ascitic fluid containing 0.03% sodium azide.Reactivity:
Human; Mouse; MonkeyRecommended Dilutions:
WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FC: 1/200-1/400, ELISA: Propose dilution 1/10000.
- Figure 1: Western blot analysis using CDH1 mouse mAb against LNCAP (1)，A431 (2), DU145 (3), PC-3 (4), MCF-7 (5), PC-12 (6), NIH/3T3 (7), C6 (8) and COS7 (9) cell lysate.
- Figure 2: Immunohistochemical analysis of paraffin-embedded gastric cancer tissues (left) and lung cancer tissues (right) using CDH1 mouse mAb with DAB staining.
- Figure 3: Flow cytometric analysis of Hela cells using CDH1 mouse mAb (green) and negative control (purple).
Price:
225$Molecular Weight:
135kDaApplications:
WB, IHC, FC, ELISA. Not yet tested in other applications.Research Area:
Autophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells
Related Products
- c-Jun (Phospho-Ser63) Antibody Datasheet COA
Catalog Number:
E011001-1Amount:
50μg/50μlReactivity:
Human, MouseApplications:
WB: 1:500~1:1000 IHC: 1:50~1:100Swiss-Prot No.:
P05412Price:
145$
- c-Jun (Phospho-Ser63) Antibody Datasheet
Catalog Number:
E011001-2Amount:
100μg/100μlReactivity:
Human, MouseApplications:
WB: 1:500~1:1000 IHC: 1:50~1:100Swiss-Prot No.:
P05412Price:
225$
- Rb Polyclonal Antibody Datasheet
Catalog Number:
E90003Amount:
100ulReactivity:
H MApplications:
WB IHCSwiss-Prot No.:
P06400Price:
225$
- Elk-1 (Phospho-Ser383) Antibody Datasheet
Catalog Number:
E011004-1Amount:
50μg/50μlReactivity:
Human, Mouse, RatApplications:
WB: 1:500~1:1000 IHC: 1:50~1:100Swiss-Prot No.:
P19419Price:
145$
- Elk-1 (Phospho-Ser383) Antibody Datasheet
Catalog Number:
E011004-2Amount:
100μg/100μlReactivity:
Human, Mouse, RatApplications:
WB: 1:500~1:1000 IHC: 1:50~1:100Swiss-Prot No.:
P19419Price:
225$
Catalog Number
- Amount:100μg/100μl
- Price:225$
Contact us
Categories by research area
Categories by product type
- Antibodies
- Tag antibodies
- Internal control antibodies
- Pathological (Immunohistochemistry, IHC) antibodies
- Cell Signal Transduction Research Antibodies
- Secondary Antibody
- Antibody Sampler Kits
- Recombinant Proteins
- Fluorescence Reagents
- Signal Inhibitors and Activators
- Transfection Reagent
- Cell biology kits