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Primary Antibodies
SIRT1 Antibody
Human; Monkey
WB, IHC, IF, FC, ELISA. Not yet tested in other applications.
$225/ 100μg/100μl
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
BackgroundThe Sir2 protein in yeast is known to function in transcriptional silencing processes through the deacetylation of histones H3 and H4. The more recently described human homologue of Sir2, known as SIRT1, has been found to associate with the tumor suppressor protein p53.SIRT1 binds and deacetylates p53 with specificity for its C-terminal Lys382 residue in response to the upregulation of promyelocytic leukemia protein (PML) nuclear bodies or oncogenic Ras. The deacetylation of p53 SIRT1 has been shown to negatively regulate p53-mediated transcription, preventing cellular senescence and apoptosis induced by DNA damage and stress.SIRT1 has the closest homology to the yeast Sir2p and is widely expressed in fetal and adult tissues, with high expression in heart, brain and skeletal muscle and low expression in lung and placenta.
Product Information
Clone Number1F3
SpeciesMouse IgG1
Entrez Gene23411
Recommended DilutionsWB: 1/500 - 1/2000, IHC: 1/200-1/1000, IF: 1/200-1/1000, FC: 1/200-1/400,
ELISA: Propose dilution 1/10000.
ELISA: Propose dilution 1/10000.
Molecular Weight120kDa
All Names
AlternameSIR2L1; SIRT1
ImmunogenPurified recombinant fragment of human SIRT1 expressed in E. Coli.
Storage/StabilityStore at 4℃, for long term storage, store at -20℃.
Form Or Antibody
Form of AntibodyAscitic fluid containing 0.03% sodium azide.
Price225$
Research AreaAutophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells
analysis of paraffin-embedded lung cancer tissues tissues (right) using SIRT1 mouse mAb with DAB staining.
analysis of NTERA-2 cells using SIRT1 mouse mAb filaments have been labeled with Alexa Fluor-555 phalloidin.
Conjugated Antibody
This product is also available conjugated. Format: E10-30086-Conjugate. Price: $485 / Size: 100μl.
E10-30086-FITC$485 / 100μlE10-30086-Biotin$485 / 100μlE10-30086-HRP$485 / 100μlE10-30086-AP$485 / 100μlE10-30086-AF350$485 / 100μlE10-30086-AF405M$485 / 100μlE10-30086-AF488$485 / 100μlE10-30086-AF514$485 / 100μlE10-30086-AF532$485 / 100μlE10-30086-AF555$485 / 100μlE10-30086-AF568$485 / 100μlE10-30086-AF405S$485 / 100μlE10-30086-AF405L$485 / 100μlE10-30086-AF546$485 / 100μlE10-30086-AF594$485 / 100μlE10-30086-AF610$485 / 100μlE10-30086-AF635$485 / 100μlE10-30086-AF647$485 / 100μlE10-30086-AF680$485 / 100μlE10-30086-AF700$485 / 100μlE10-30086-AF750$485 / 100μlE10-30086-AF790$485 / 100μlE10-30086-APC$485 / 100μlE10-30086-PE$485 / 100μlE10-30086-Cy3$485 / 100μlE10-30086-Cy5$485 / 100μlE10-30086-Cy5.5$485 / 100μlE10-30086-Cy7$485 / 100μlE10-30086-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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