World supplier of antibodies, antigens and kits since 2007
Primary Antibodies
XBP1 Antibody
Human
WB, ELISA. Not yet tested in other applications.
$225/ 100μg/100μl
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
BackgroundThis gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.
Product Information
Clone Number1C4
SpeciesMouse IgG1
Entrez Gene7494
Recommended DilutionsWB: 1/500 - 1/2000, ELISA: Propose dilution 1/10000.
Molecular Weight28kDa
All Names
AlternameXBP2; TREB5; XBP1
ImmunogenPurified recombinant fragment of human XBP1 expressed in E. Coli.
Storage/StabilityStore at 4℃, for long term storage, store at -20℃.
Form Or Antibody
Form of AntibodyAscitic fluid containing 0.03% sodium azide.
Price225$
Research AreaAutophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells
blot analysis using XBP1 mouse mAb against HEK293 cell lysate.
Conjugated Antibody
This product is also available conjugated. Format: E10-30035-Conjugate. Price: $485 / Size: 100μl.
E10-30035-FITC$485 / 100μlE10-30035-Biotin$485 / 100μlE10-30035-HRP$485 / 100μlE10-30035-AP$485 / 100μlE10-30035-AF350$485 / 100μlE10-30035-AF405M$485 / 100μlE10-30035-AF488$485 / 100μlE10-30035-AF514$485 / 100μlE10-30035-AF532$485 / 100μlE10-30035-AF555$485 / 100μlE10-30035-AF568$485 / 100μlE10-30035-AF405S$485 / 100μlE10-30035-AF405L$485 / 100μlE10-30035-AF546$485 / 100μlE10-30035-AF594$485 / 100μlE10-30035-AF610$485 / 100μlE10-30035-AF635$485 / 100μlE10-30035-AF647$485 / 100μlE10-30035-AF680$485 / 100μlE10-30035-AF700$485 / 100μlE10-30035-AF750$485 / 100μlE10-30035-AF790$485 / 100μlE10-30035-APC$485 / 100μlE10-30035-PE$485 / 100μlE10-30035-Cy3$485 / 100μlE10-30035-Cy5$485 / 100μlE10-30035-Cy5.5$485 / 100μlE10-30035-Cy7$485 / 100μlE10-30035-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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