BackgroundThis gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
Product Information
Clone Number7A10
SpeciesMouse IgG1
Entrez Gene142
Recommended DilutionsWB: 1/500 - 1/2000, FC: 1/200-1/400, ELISA: Propose dilution 1/10000.
Molecular Weight117kDa
All Names
AlternamePARP; PPOL; ADPRT; ADPRT1; PARP-1; pADPRT-1; PARP1
ImmunogenSynthetic peptide of human PARP, conjugated to KLH.
Storage/StabilityStore at 4℃, for long term storage, store at -20℃.
Form Or Antibody
Form of AntibodyAscitic fluid containing 0.03% sodium azide.
Research AreaAutophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells