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Primary Antibodies
GSK3B Antibody
Human; Rat; Mouse; Monkey
WB, IHC, IF, FC, ELISA. Not yet tested in other applications.
$225/ 100μg/100μl
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
BackgroundGlycogen synthase kinase 3 (GSK-3), a serine-threonine kinase with two isoforms (alpha and beta), was originally discovered as a key enzyme in glycogen metabolism. GSK-3 was subsequently shown to function in cell division, proliferation, motility and survival. GSK-3 plays a role in a number of pathological conditions including cancer and diabetes and is increasingly seen as an important component of neurological diseases. GSK-3 phosphorylates tau and presenilin-1, which are involved in the development of Alzheimer's disease. Both isoforms of GSK-3 are ubiquitously expressed, although particularly high levels of GSK-3beta are found in the brain where it is involved in synaptic plasticity, possibly via regulation of NMDA receptor trafficking. GSK-3 phosphorylates over 40 different substrates including signaling proteins, transcription factors and structural proteins, and is part of the signal transduction cascade of a large number of growth factors and cytokines.
Product Information
Clone Number3D10
SpeciesMouse IgG1
Entrez Gene2942
Recommended DilutionsWB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF: 1/200-1/1000, FC: 1/200-1/400,
ELISA: Propose dilution 1/10000.
ELISA: Propose dilution 1/10000.
Molecular Weight46kDa
All Names
AlternameGSK-3β; GSK3-beta
ImmunogenPurified recombinant fragment of human GSK3B expressed in E. Coli.
Storage/StabilityStore at 4℃, for long term storage, store at -20℃.
Form Or Antibody
Form of AntibodyAscitic fluid containing 0.03% sodium azide.
Price225$
Research AreaAutophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells
analysis of paraffin-embedded human lung cancer (left) and using GSK3B mouse mAb with DAB staining.
analysis of NIH/3T3 (left) and U251 (right) cells using GSK3B DRAQ5 fluorescent DNA dye. Red: Actin filaments have been phalloidin.
Conjugated Antibody
This product is also available conjugated. Format: E10-30006-Conjugate. Price: $485 / Size: 100μl.
E10-30006-FITC$485 / 100μlE10-30006-Biotin$485 / 100μlE10-30006-HRP$485 / 100μlE10-30006-AP$485 / 100μlE10-30006-AF350$485 / 100μlE10-30006-AF405M$485 / 100μlE10-30006-AF488$485 / 100μlE10-30006-AF514$485 / 100μlE10-30006-AF532$485 / 100μlE10-30006-AF555$485 / 100μlE10-30006-AF568$485 / 100μlE10-30006-AF405S$485 / 100μlE10-30006-AF405L$485 / 100μlE10-30006-AF546$485 / 100μlE10-30006-AF594$485 / 100μlE10-30006-AF610$485 / 100μlE10-30006-AF635$485 / 100μlE10-30006-AF647$485 / 100μlE10-30006-AF680$485 / 100μlE10-30006-AF700$485 / 100μlE10-30006-AF750$485 / 100μlE10-30006-AF790$485 / 100μlE10-30006-APC$485 / 100μlE10-30006-PE$485 / 100μlE10-30006-Cy3$485 / 100μlE10-30006-Cy5$485 / 100μlE10-30006-Cy5.5$485 / 100μlE10-30006-Cy7$485 / 100μlE10-30006-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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