BackgroundThis gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.
Product Information
Clone Number2G4
SpeciesMouse IgG1
Entrez Gene1107
Recommended DilutionsWB 1/500 - 1/2000,IHC: 1/200 - 1/1000.IF: 1/200 - 1/1000.FC:1/200 - 1/400.ELISA: Propose dilution 1/10000.
Molecular Weight226kDa
All Names
AlternameZFH; Mi-2a; Mi2-ALPHA; CHD3
ImmunogenPurified recombinant fragment of human CHD3 expressed in E. Coli.
Storage/StabilityStore at 4℃, for long term storage, store at -20℃
Form Or Antibody
Form of AntibodyAscitic fluid containing 0.03% sodium azide.
Research AreaAutophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells