BackgroundMATK (megakaryocyte-associated tyrosine kinase), also known as CTK, this protein has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer.
Product Information
Clone Number9D7
SpeciesMouse IgG1
Entrez Gene4145
Recommended DilutionsWB: 1/500 - 1/2000. FC: 1/200 - 1/400. ELISA: Propose dilution 1/10000.
Molecular Weight56kDa
All Names
AlternameCHK; CTK
ImmunogenPurified recombinant fragment of human MATK expressed in E. Coli.
Storage/StabilityStore at 4℃, for long term storage, store at -20℃
Form Or Antibody
Form of AntibodyAscitic fluid containing 0.03% sodium azide.
Research AreaAutophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells