BackgroundRTN3, reticulon 3. The reticulons are a group of highly conserved genes with preferential expression in neuroendocrine tissues. RTN3 may be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. There are 5 isoforms.
Product Information
Clone Number3B5
SpeciesMouse IgG2a
Entrez Gene10313
Recommended DilutionsIHC: 1/200 - 1/1000.ELISA: Propose dilution 1/10000.
Molecular Weight113kDa
All Names
AlternameHAP; ASYIP; NSPL2; NSPLII; RTN3-A1
ImmunogenPurified recombinant fragment of RTN3 expressed in E. Coli.
Storage/StabilityStore at 4℃, for long term storage, store at -20℃
Form Or Antibody
Form of AntibodyAscitic fluid containing 0.03% sodium azide.
Research AreaAutophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells