BackgroundFGFR4: fibroblast growth factor receptor 4. Entrez Protein NP_002002. It is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3.
Product Information
Clone Number7H1
SpeciesMouse IgG1
Entrez Gene2264
Recommended DilutionsWB:1/500 - 1/2000.IF:1/200 - 1/1000.ELISA: Propose dilution 1/10000.
Molecular Weight87.9kDa
All Names
AlternameTKF; JTK2; CD334
ImmunogenPurified recombinant extracellular fragment of human FGFR4 fused with hIgGFc tag expressed in HEK293 cell line.
Storage/StabilityStore at 4℃, for long term storage, store at -20℃
Form Or Antibody
Form of AntibodyAscitic fluid containing 0.03% sodium azide.
Research AreaAutophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells