BackgroundPEG10: paternally expressed 10. This gene includes two overlapping reading frames of the same transcript encoding distinct isoforms. The shorter isoform has a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons, and it functions in part by interacting with members of the TGF-beta receptor family. The longer isoform has the active-site DSG consensus sequence of the protease domain of pol proteins. The longer isoform is the result of -1 translational frameshifting that is also seen in some retroviruses. Expression of these two isoforms only comes from the paternal allele due to imprinting. Increased gene expression (as observed by an increase in mRNA levels) is associated with hepatocellular carcinomas.
Product Information
Clone Number1B1C4
SpeciesMouse IgG1
Entrez Gene23089
Recommended DilutionsWB:1/500 - 1/2000.IHC:1/200 - 1/1000.IF:1/200 - 1/1000.ELISA: Propose dilution 1/10000.
All Names
AlternameEdr; HB-1; Mar2; MEF3L; Mart2; RGAG3; KIAA1051
ImmunogenPurified recombinant fragment of PEG10 (aa1-120) expressed in E. Coli.
Storage/StabilityStore at 4℃, for long term storage, store at -20℃
Form Or Antibody
Form of AntibodyAscitic fluid containing 0.03% sodium azide.
Research AreaAutophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells