BackgroundAmyloid precursor protein(APP) ,with 32-amino acid protein (about 35 kDa), is part of a super-family of transmembrane and secreted proteins. It appears to have a number of roles, including regulation of haemostasis and mediation of neuroprotection. APP undergoes alternative splicing, resulting in several isoforms . Proteolytic cleavage of amyloid precursor protein leads to the formation of the 4 kDa amyloid beta/A4 protein, which is present in human platelets. APP is also involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer patients.
Product Information
Clone Number1B11F3
SpeciesMouse IgG2a
Entrez Gene351
Recommended DilutionsWB:1/500 - 1/2000, IHC:1/200 - 1/1000, ELISA: Propose dilution 1/10000.
ImmunogenPurified recombinant fragment of APP expressed in E. Coli.
Storage/StabilityStore at 4℃, for long term storage, store at -20℃
Form Or Antibody
Form of AntibodyAscitic fluid containing 0.03% sodium azide.
Research AreaAutophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells