BackgroundBcl-10 (B-cell CLL/lymphoma 10), also known as CLAP, Me10, CIPER, c-E10, CARMEN. Entrez Protein NP_003912. It is a protein containing a caspase recruitment domain (CARD). It plays an important role in apoptosis and activating NF-kappaB. The research suggested that it interacted with other CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-kappaB signaling. Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
Product Information
Clone Number4F8
SpeciesMouse IgG1
Entrez Gene8915
Recommended DilutionsWB.1/500 - 1/2000, IHC.1/200 - 1/1000, IF.1/200 - 1/1000, FCM.1/200 - 1/400 ELISA. Propose dilution 1/10000.
Molecular Weight26kDa
All Names
AlternameCLAP; Me10; CIPER; c-E10; CARMEN
ImmunogenPurified recombinant fragment of human BCL-10 expressed in E. Coli.
Storage/StabilityStore at 4℃, for long term storage, store at -20℃
Form Or Antibody
Form of AntibodyPurified antibody in PBS containing 0.03% sodium azide.
Research AreaAutophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells