BackgroundNucleophosmin (NPM), also named B23 or NO38, is a major nucleolar protein which is 20 times more abundant in tumor or proliferating cells than in normal resting cells. NPM has been implicated in several distinct cellular functions, including assembly and transport of ribosomes, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication and molecular chaperoning activities. The NPM portion contributes to transformation by providing a dimerization domain, which results in activation of the fused kinase.
Product Information
Clone Number7H10B9
SpeciesMouse IgG1
Entrez Gene4869
Recommended DilutionsWB.1/500 - 1/2000, IHC.1/200 - 1/1000, IF.1/200 - 1/1000, ELISA.Propose dilution 1/10000.
Molecular Weight33kDa
All Names
AlternameB23; NPM
ImmunogenPurified recombinant fragment of human NPM expressed in E. Coli.
Storage/StabilityStore at 4℃, for long term storage, store at -20℃.
Form Or Antibody
Form of AntibodyAscitic fluid containing 0.03% sodium azide.
Research AreaAutophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells