Form Or Antibody
Form of AntibodyRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage/StabilityStore at -20℃/1 year
ImmunogenThe antiserum was produced against synthesized phosphopeptide derived from human Tau around the phosphorylation site of serine 404 (D-T-SP-P-R).
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
Specificty Sensitivity
Specificity/SensitivityTau (phospho-Ser404) antibody detects endogenous levels of Tau only when phosphorylated at serine404.
ReferencesLi G, Yin H, et.al .(2004) J Biol Chem ; 279(16): 15938-45.
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Giasson BI, et al.(2002).. Biochemistry; 41(51): 15376-87.
Lee G., et.al. (1989). Neuron 2:1615-1624.
Andreadis A.,et.al. (1992) Biochemistry 31:10626-10633.
Research AreaAutophagy antibody Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction Stem Cells