You are here: EnoGene Home > Products > Signal Inhibitors and Activators > LY-294002PI3K Inhibitor

LY-294002PI3K Inhibitor
Datasheet   

  • Catalog Number:

    E1B1737

  • Amount:

  • PHYSICAL APPEARANCE: Off-white-pale yellow solid (m.p. 182-184°C)
    MOLECULAR FORMULA: C19H17NO3

  • Molecular Weight:

    307.4

  • Purity:

    99% (TLC)

  • Solubility:

    Soluble in DMSO (25 mg/ml warm) and ethanol (25 mg/ml warm)

  • Storage/Stability:

    Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.

  • Recommended Dilutions:

    Potent, cell permeable and specific inhibitor of phosphatidylinositol 3- kinase (IC50 = 1.4 μM; purified PI 3-kinase). Does not significantly inhibit PKC, PKA, MAP kinase, S6 kinase, EGFrK, c-src kinase, PI 4-kinase, DAG kinase or rabbit kidney ATPase at concentrations of 50 μM. In intact neutrophils stimulated with fMet-Leu-Phe, LY 294002 completely abolished PI 3-kinase activity at 50 μM without cell toxicity. Also blocked proliferation of cultured rabbit aortic smooth muscle cells without cell death. Induces apoptosis.

  • References:

    1​ C.J.Vlahos et al. J.Biol.Chem. 1994 269 5241
    2​ V.Sanchez Margalet et al. Biochem.Biophys.Res.Commun. 1994 204 446
    3​ T.J.Kovacsovics et al. J.Biol.Chem. 1995 270 11358
    4​ R.Yao and G.M.Cooper Science 1995 267 2003
    The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.

  • Price:

    55$

Related Products

BAY 11-7082NF-κB Inhibitor Datasheet   

  • Catalog Number:

    E1B1523

  • Amount:

  • Reactivity:

  • Applications:

  • Swiss-Prot No.:

  • Price:

    60.00$
U 0126 Datasheet   

  • Catalog Number:

    E1B1901

  • Amount:

    1mg

  • Reactivity:

  • Applications:

  • Swiss-Prot No.:

  • Price:

    85.00$
Forskolin Datasheet   

  • Catalog Number:

    E1B1612

  • Amount:

  • Reactivity:

  • Applications:

  • Swiss-Prot No.:

  • Price:

    50.00$
H-89PKA Inhibitor Datasheet   

  • Catalog Number:

    E1B1643

  • Amount:

  • Reactivity:

  • Applications:

  • Swiss-Prot No.:

  • Price:

    40.00$
Rapamycin Datasheet   

  • Catalog Number:

    E1B1842

  • Amount:

    0.1mg

  • Reactivity:

  • Applications:

  • Swiss-Prot No.:

  • Price:

    60.00$

Catalog Number

  • Amount:
  • Price:55.00$

AbPromise

Contact us