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Forskolin
Datasheet   

  • Catalog Number:

    E1B1612

  • Amount:

  • PHYSICAL APPEARANCE: White solid, mp=229-232°C
    MOLECULAR FORMULA: C22H34O7

  • Molecular Weight:

    410.5

  • Purity:

    99% (TLC)

  • Storage/Stability:

    Store solutions at -20°C for up to 1 year.

  • Recommended Dilutions:

    Activates adenylate cyclase by directly interacting with the catalytic subunit of the enzyme EC50=2-10 μM. Cell permeable and active in vivo. Most cell culture studies employ a working concentration of 5 or 10 μM. Do not make stock solutions in ethanol. Ethanol inhibits forskolin activation of adenylate cyclase. 1,9-Dideoxyforskolin may be used as a negative control.

  • References:

    1) Merck Index 13, 2500
    2) Review K.B. Seamon Annu. Rep. Med. Chem. 1984 19 293
    3) K.B. Seamon and J.W. Daly Adv. Cyclic Nucl. Res. 1986 20 1
    4) A. Laurenza et al. Trends Pharmacol. Sci. 1989 10 442
    5) N.J. De Souza et al. Med. Res. Rev. 1983 3 201
    6) R.D. Huang J. Cyclic Nucl. Res. 1982 8 385
    The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.

  • Price:

    50$

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