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Rapamycin
Datasheet   

  • Catalog Number:

    E1B1842

  • Amount:

    0.1mg

  • PHYSICAL APPEARANCE: Off-white or yellow solid
    MOLECULAR FORMULA: C51H79NO13

  • Molecular Weight:

    914.2

  • Purity:

    98% (TLC: 10% MeOH/Methylene chloride; Rf = 0.51)

  • Storage/Stability:

    Store solutions at -20°C for up to 1 year.

  • Recommended Dilutions:

    Binds to and inhibits the FK506 binding protein (FKBP) proline rotamase. Rapamycin is bound simultaneously by FKBP12 and FRAP (FKBP12-Rapamycin-Associated-Protein). Rapamycin/FKBP complex does not inhibit FRAP PI 4-kinase activity, but does inhibit FRAP autophosphorylation. Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 to S phase. Rapamycin selectively blocks signaling leading to the activation of p70/85 S6 kinase.

  • References:

    1. J.Y.Chang et al. Trends Pharmacol.Sci. 1991 12 218
    2. J.Choi et al. Science 1996 273 183
    3. D.M.Sabatini et al. J.Biol.Chem. 1995 270 20875
    4. E.J.Brown et al. Nature 1995 377 441
    5. J.E.Kay et al. Immunology 1991 72 544
    6. W.G.Morice et al. J.Biol.Chem. 1993 268 3734
    7. J.Heitman et al. Science 1991 253 905
    8. D.J.Price et al. Science 1992 257 973
    9. D.C.Fingar et al. J.Biol.Chem. 1993 268 3005
    10. J.Chung et al. Cell 1992 69 1227
    The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.

  • Price:

    60$

  • Form of Antibody:

    RapamycinCAS NO: 53123-88-9

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Catalog Number

  • Amount:0.1mg
  • Price:60.00$

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