SARS-CoV-2 Spike RBD Polyclonal Antibody
Datasheet
Catalog Number:
EGVR1002Amount:
100ugSource:
RabbitIsotype:
IgGImmunogen:
The antibody was developed by immunizing rabbits with synthetic peptides corresponding to amino acids range 400-460aa of the surface glycoprotein.Purification:
The antibody was Protein A purified from rabbit antiserum by affinity-chromatography.Reactivity:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Specificity/Sensitivity:
The antibody reacts specific to Spike Protein (surface glycoprotein) RBD domain of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19 (100%) (YP_009724390.1).Applications:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.Storage/Stability:
/ Stability:Store at 4°C for short term. Aliquot and store at -20°C for one year. Avoid freeze-thaw cycles.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% Proclin300.Background:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined. The structural proteins of SARS-CoV-2 include the envelope protein (E), spike or surface glycoprotein (S), membrane protein (M) and the nucleocapsid protein (N). The spike glycoprotein is found on the outside of the virus particle and gives coronavirus viruses their crown-like appearance. This glycoprotein mediates attachment of the virus particle and entry into the host cell. S protein is an important target for vaccine development, antibody therapies and diagnostic antigen- based tests. Two spike antigens are currently widely used: the receptor binding domain (RBD), which interacts with the extracellular ACE2 receptor, and a much larger soluble spike ectodomain modified for stability to mimic the prefusionnative spike trimer conformation.Price:
395$
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Catalog Number
- Amount:100ug
- Price:395$
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