TNFRSF1B Polyclonal Antibody
Datasheet
Catalog Number:
E91095Amount:
100ulBackground:
TNF-α is an important cytokine produced by numerous cell types including neutrophils, activated lymphoctyes, macrophages an NK cells. It plays a critical role in inflammatory responses and in apoptosis (1). TNF-α exists as a membrane-anchored and soluble form, both of which show biological activity. Response to TNF-α is mediated through two receptors, TNF-R1, which is widely expressed, and TNF-R2, which is expressed mainly in immune and endothelial cells (2). Antagonists to TNF-α have been validated as therapeutic targets for rheumatoid arthritis and other immune disorders (3). The two receptors for TNF-α, TNF-R1 (55 kDa) and TNF-R2 (75 kDa) can mediate distinct cellular responses (4,5). In most cases cytotoxicity elicited by TNF has been reported to act throught TNF-R1 (6,7). In contrast, TNF-R2 appears to be important in T cell signaling and responses to infection (7,8). TNF-R2 binds to distinct members of the TRAF family leading to the activation of NF-κB (9,10). Soluble forms of both receptors have also been characterized which can bind TNF-α and may play an important role in immune disorders (11,12). TSpecies:
RabbitIsotype:
IgGStorage/Stability:
Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.Altername:
TNFRSF1B;CD120b;TBPII;TNF-R-II;TNF-R75;TNFBR;TNFR1B;TNFR2;TNFR80;p75;p75TNFR ;Immunogen:
Recombinant protein of human TNFRSF1BPurification:
Affinity purificationReactivity:
H M RApplications:
WB IHCMolecular Weight:
48kDaSwiss-Prot No.:
P20333Gene ID:
7133References:
1. Aggarwal, B.B. (2003) Nat Rev Immunol 3, 745-56. 2. Locksley, R.M. et al. (2001) Cell 104, 487-501. 3. Taylor, P.C. et al. (2004) Curr Opin Biotechnol 15, 557-63. 4. Tartaglia, L.A. et al. (1991) Proc. Natl. Acad. Sci. USA 88, 9292-9296. 5. Peschon, J.J. et al. (1998) J. Immunol. 160, 943-952. 6. Tartaglia, L.A. et al. (1993) Cell 73, 213-216. 7. Rothe, J. et al. (1993) Nature 364, 798-802. 8. Aspalter, R.M. et al. (2003) J. Leukoc. Biol. 74, 572-582. 9. Rothe, M. et al. (1994) Cell 78, 681-692. 10. Rothe, M. et al. (1995) Science 269, 1424-1427. 11. Humbert, M. et al. (1994) Am. J. Respir. Crit. Care Med. 149, 1681-1685. 12. Schröder, J. et al. (1995) Infection 23, 143-8.
WB 1:500 - 1:2000
IHC 1:50- 1:200
- Western blot analysis of 293 cell and MCF7 cell lysate using TNFRSF1B antibody.
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