ACTR3Polyclonal Antibody
Datasheet
Catalog Number:
E91064Amount:
100ulBackground:
Actin nucleation, the formation of new actin filaments from existing filaments, affects actin filament structure during cell motility, division, and intracellular trafficking. An important actin nucleation protein complex is the highly conserved ARP2/3 complex, consisting of ARP2, ARP3, and ARPC1-5. The ARP2/3 complex promotes branching of an existing actin filament and formation of a daughter filament following activation by nucleation-promoting factors, such as WASP/WAVE or cortactin (1). The formation of podosomes, small cellular projections that degrade the extracellular matrix, is enhanced by ARP2/3 complex action. ARP2/3 competes with caldesmon, an actin binding protein shown to negatively affect podosome formation (2). Along with N-WASP, the ARP2/3 complex regulates nuclear actin filament nucleation and controls actin polymerization during transcription (3).Species:
RabbitIsotype:
IgGStorage/Stability:
Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.Altername:
ACTR3;ARP3 ;Immunogen:
Recombinant proteinof human ACTR3Purification:
Affinity purificationReactivity:
H M RApplications:
WB IHCMolecular Weight:
47kDaSwiss-Prot No.:
P61158Gene ID:
10096References:
1. Goley, E.D. and Welch, M.D. (2006) Nat. Rev. Mol. Cell Biol. 7, 713-726. 2. Morita, T. et al. (2007) J. Biol. Chem. 282, 8454-8463. 3. Yoo, Y. et al. (2007) J. Biol. Chem. 282, 7616-7623.
WB 1:500 - 1:2000
IHC 1:50- 1:200
- Western blot analysis of extracts of various celllines, using ACTR3 antibody.
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