STAR Polyclonal Antibody | EnoGene Biotech Co. Ltd

STAR Polyclonal Antibody
Datasheet

Catalog Number:
E91035
Amount:
100ul
Background:
Steroidogenic acute regulatory protein (StAR) plays a significant role in cholesterol transport from the cytoplasmic outer membrane to the inner mitochondrial membrane (1). The 37 kDa precursor is cleaved to generate an active 28 kDa protein capable of facilitating cholesterol metabolism into pregnenolone (2,3). StAR is prevalently expressed in mitochondria of steroid-producing adrenal and gonadal tissue (3). Abnormalities in StAR gene expression are impacted in autosomal Lipoid Congenial Adrenal Hyperplasia (LCAH) resulting in defects in pregnenolone and cortisol synthesis (4). The mechanism of cholesterol binding to StAR has yet to be elucidated (4).
Species:
Rabbit
Isotype:
IgG
Storage/Stability:
Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Altername:
STAR;STARD1 ;
Immunogen:
Recombinant protein of human STAR
Purification:
Affinity purification
Reactivity:
H M R
Applications:
WB IHC
Molecular Weight:
32kDa
Swiss-Prot No.:
P49675
Gene ID:
6770
References:
1. Caron, K.M. et al. (1997) Proc Natl Acad Sci U S A 94, 11540-5. 2. Bose, H.S. et al. (1999) Proc Natl Acad Sci U S A 96, 7250-5. 3. Manna, P.R. et al. (2002) Biol Reprod 67, 1393-404. 4. Roostaee, A. et al. (2008) Biochem J 412, 553-62.
WB 1:500 - 1:2000
IHC 1:50- 1:200
Western blot analysis of SK-BR-3 cell lysateusing STAR antibody.

STAR Polyclonal Antibody
Datasheet