ENO1Polyclonal Antibody
Datasheet
Catalog Number:
E91033Amount:
100ulBackground:
Enolase is an important glycolytic enzyme involved in the interconversion of 2-phosphoglycerate to phosphoenolpyruvate. Mammalian enolase exists as three subunits: enolase-1 (α-enolase), enolase-2 (γ-enolase) and enolase-3 (β-enolase) that can form both homo- and heterodimers. Expression of the enolase isoforms differs in a tissue specific manner (1). Enolase-1 plays a key role in anaerobic metabolism under hypoxic conditions and may act as a cell surface plasminogen receptor during tissue invasion (2,3). Abnormal expression of enolase-1 is associated with tumor progression in some cases of breast and lung cancer (4-7). Alternatively, an enolase-1 splice variant (MBP-1) binds the c-myc promoter p2 and may function as a tumor suppressor. For this reason enolase-1 is considered as a potential therapeutic target in the treatment of some forms of cancer (8).Species:
RabbitIsotype:
IgGStorage/Stability:
Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.Altername:
ENO1;ENO1L1;MBP-1;MPB1;NNE;PPH ;Immunogen:
Recombinant proteinof human ENO1Purification:
Affinity purificationReactivity:
H M RApplications:
WB IHCMolecular Weight:
47kDaSwiss-Prot No.:
P06733Gene ID:
2023References:
1. Pancholi, V. (2001) Cell Mol Life Sci 58, 902-20. 2. Redlitz, A. et al. (1995) Eur J Biochem 227, 407-15. 3. Jiang, B.H. et al. (1997) Cancer Res 57, 5328-35. 4. Peebles, K.A. et al. (2003) Carcinogenesis 24, 651-7. 5. Zhang, L. et al. (2000) J Surg Res 93, 108-19. 6. Wu, W. et al. (2002) Clin Exp Metastasis 19, 319-26. 7. Hennipman, A. et al. (1988) Tumour Biol 9, 241-8. 8. Feo, S. et al. (2000) FEBS Lett 473, 47-52.
WB 1:500 - 1:2000
IHC 1:50- 1:200
- Western blot analysis of extracts of various cell lines, using ENO1 antibody.
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