IL2Polyclonal Antibody
Datasheet
Catalog Number:
E90302Amount:
100ulBackground:
IL-2 is a T cell stimulatory cytokine best known for inducing T cell proliferation and NK cell proliferation and activation (1,2). IL-2 also promotes peripheral development of Treg cells (4, 5). Conversely, IL-2 is involved in activation induced cell death (AICD) that is observed post T cell expansion by increasing levels of Fas on CD4+ T cells (3). The effects of IL-2 are mediated through a trimeric receptor complex consisting of IL-2Rα, IL-2Rβ and the common gamma chain, γc (1,2). IL-2 Rα binds exclusively to IL-2 with low affinity and increases binding affinity of the whole receptor complex including IL-2Rβ and γc subunits. IL-2Rβ is also used by IL-15 (1,2). The common γc is used by other cytokines including IL-4, IL-7, IL-9, IL-15, and IL-21 (1,2). Binding of IL-2 initiates signaling cascades involving Jak1, Jak3, Stat5 and the PI3K/Akt pathways (1,2).Species:
RabbitIsotype:
IgGStorage/Stability:
Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.Altername:
IL2;IL-2;TCGF;lymphokine ;Immunogen:
Recombinant proteinof human IL2Purification:
Affinity purificationReactivity:
HApplications:
WB IHC ICCMolecular Weight:
18kDaSwiss-Prot No.:
P60568Gene ID:
3558References:
1. Ma, A. et al. (2006) Annu Rev Immunol 24, 657-79. 2. Gaffen, S.L. and Liu, K.D. (2004) Cytokine 28, 109-23. 3. Jaleco, S. et al. (2003) J Immunol 171, 61-8. 4. Fehérvari, Z. et al. (2006) Trends Immunol 27, 109-11. 5. Antony, P.A. et al. (2006) J Immunol 176, 5255-66.
WB 1:500 - 1:2000
IHC 1:50- 1:200
ICC 1:50- 1:200
- Western blot analysis of CTLL-2 cell lysate using IL-2 antibody.
Related Products
- BRCA1 (Phospho-Ser1524) Antibody Datasheet
Catalog Number:
E011117-1Amount:
50μg/50μlReactivity:
HumanApplications:
IHC: 1:50~1:100Swiss-Prot No.:
P38398Price:
145$
- BRCA1 (Phospho-Ser1524) Antibody Datasheet
Catalog Number:
E011117-2Amount:
100μg/100μlReactivity:
HumanApplications:
IHC: 1:50~1:100Swiss-Prot No.:
P38398Price:
225$
- JAK1(Phospho-Tyr1022) Antibody Datasheet
Catalog Number:
E011149-1Amount:
50μg/50μlReactivity:
Human, Mouse, RatApplications:
WB: 1:500~1:1000 IHC: 1:50~1:100Swiss-Prot No.:
P23458Price:
145$
- JAK1(Phospho-Tyr1022) Antibody Datasheet
Catalog Number:
E011149-2Amount:
100μg/100μlReactivity:
Human, Mouse, RatApplications:
WB: 1:500~1:1000 IHC: 1:50~1:100Swiss-Prot No.:
P23458Price:
225$
- BRCA1 (Phospho-Ser988) Antibody Datasheet
Catalog Number:
E011237-1Amount:
50μg/50μlReactivity:
HumanApplications:
IF:1:100~1:200Swiss-Prot No.:
P38398Price:
145$
Catalog Number
- Amount:100ul
- Price:255$
Contact us
Categories by research area
Categories by product type
- Antibodies
- Tag antibodies
- Internal control antibodies
- Pathological (Immunohistochemistry, IHC) antibodies
- Cell Signal Transduction Research Antibodies
- Secondary Antibody
- Antibody Sampler Kits
- Recombinant Proteins
- Fluorescence Reagents
- Signal Inhibitors and Activators
- Transfection Reagent
- Cell biology kits