Product Information
Product TypeMouse monoclonal IgG2a, primary antibodies
Species reactivityHuman
Molecular Wt99 kDa
Clone NumberG2-G9
DescriptionThe mGluR proteins (metabotropic Glutamate Receptors) are members of the G-proteincoupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic Glutamate Receptors). The eight currently known mGluR proteins are mediated by two G-proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR1 and mGluR5 are mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calciumactivated chloride current. The remainder of the eight sub-types of mGluR have an activity mediated by a G-protein that inhibits adenylate cyclase activity. mGluR-3, which may interact with GRASP, acts as a receptor for glutamate.
Positive controlHuman GRM3 recombinant protein, GRM3-hIgGFc transfected HEK293 cell lysate, Hela, human cervical cancer tissue, SH-SY5Y.
Subcellular LocationCell membrane
SwissProtQ14832 Human
Recommended DilutionsWB 1:500-1:2,000
ICC 1:50-1:200
IHC-P 1:50-1:200
FC 1:50-1:100
Storage Buffer1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Storage InstructionStore at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
PurityProtein A affinity purified.