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LITAF Antibody (N-Term)
Datasheet   

  • Catalog Number:

    E45R33402G-4

  • Amount:

    50 µl

  • Cite ID#:

    EN5479497

  • Price:

    295$

  • Type:

    Rabbit Polyclonal Antibody

  • Host:

    Rabbit

  • Reactivity:

    H

  • Immunogen:

    This LITAF antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 31-60 amino acids from the human LITAF.

  • Purification:

    Affinity chromatography purified.

  • Gene Name:

    LITAF

  • Gene ID:

    9516

  • Swiss-Prot No.:

    Q99732

  • Function:

    Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation (PubMed:23166352). Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps downregulate downstream signaling cascades (PubMed:23166352). Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes (PubMed:23166352). Probably plays a role in regulating protein degradation via its interaction with NEDD4 (PubMed:15776429). May also contribute to the regulation of gene expression in the nucleus (PubMed:10200294, PubMed:15793005). Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines (PubMed:15793005). May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10 (PubMed:10200294, PubMed:15793005).

  • Summary:

    Tissue Location:
    Ubiquitously and abundantly expressed. Expressed predominantly in the placenta, peripheral blood leukocytes, lymph nodes and spleen.

  • Storage/Stability:

    Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

  • Applications:

    WB

  • Dilution:

    WB--1:1000

  • Altername:

    Lipopolysaccharide-induced tumor necrosis factor-alpha factor, LPS-induced TNF-alpha factor, Small integral membrane protein of lysosome/late endosome, p53-induced gene 7 protein, LITAF, PIG7, SIMPLE

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LITAF Antibody (N-Term) | EnoGene Biotech Co. Ltd