You are here: EnoGene Home > Products > SGTA Antibody (Center)

SGTA Antibody (Center)
Datasheet   

  • Catalog Number:

    E45R31352G-1

  • Amount:

    100 µl

  • Cite ID#:

    EN5487933

  • Price:

    395$

  • Type:

    Rabbit Polyclonal Antibody

  • Host:

    Rabbit

  • Reactivity:

    M

  • Immunogen:

    This SGTA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-106 amino acids from the Central region of human SGTA.

  • Purification:

    Affinity chromatography purified.

  • Gene Name:

    SGTA

  • Gene ID:

    6449

  • Swiss-Prot No.:

    O43765

  • Function:

    Co-chaperone that binds misfolded and hydrophobic patches- containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail- anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892, PubMed:25535373). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457).

  • Summary:

    Tissue Location:
    Ubiquitous.

  • Form:

    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

  • Storage/Stability:

    Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

  • Applications:

    WB

  • Dilution:

    WB--1:1000

  • Altername:

    Small glutamine-rich tetratricopeptide repeat-containing protein alpha, Alpha-SGT, Vpu-binding protein, UBP, SGTA, SGT, SGT1

Add to Cart

Related Products

Catalog Number

  • Amount:100 µl
  • Price:395$

Add to Cart

AbPromise

Contact us