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Phospho-RIPK1-S166 Rabbit pAb

E45R30285NDatasheetCOAMSDS
Human, Mouse,
WB (Homo sapiens)
Q60855
$510/ 100 µl
Quantity
Total: $510

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

Product Information

Cite ID#EN5518320
TypePhosphorylated Antibodies
HostRabbit
Positive controlNIH/3T3
IsotypeIgG
SummarySerine-threonine kinase which is a key regulator of both cell death and cell survival (PubMed:25459879). Exhibits kinase activity-dependent functions that trigger cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:31519887, PubMed:31519886). Initiates ripoptocide which describes cell death that is dependent on RIPK1, be it apoptosis or necroptosis (PubMed:31457011). Upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kB pathway (PubMed:31519887, PubMed:31519886). Specific conditions can however activate RIPK1, and its kinase activity then regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8) and the complex IIb (RIPK1-RIPK3-MLKL) and these complexes respectively drive apoptosis or necroptosis, a regulated form of necrosis (PubMed:29440439, PubMed:30988283). During embryonic development suppresses apoptosis and necroptosis and prevents the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (PubMed:30867408, PubMed:30185824). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (By similarity). Required for ZBP1-induced NF-kappaB activation and activation of NF-kappaB by DNA damage and IR.
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Price510$
ImmunogenA phospho specific peptide corresponding to residues surrounding S166 of Mouse RIPK1.
PurificationAffinity purification
Gene ID19766
Storage/StabilityStore at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
DilutionWB 1:500 - 1:2000

All Names

AlternameD330015H01Rik; RIP; Rinp; Rip1
📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Certificate of Analysis (PDF)🧪MSDS
Material safety data sheet (PDF)

Conjugated Antibody

This product is also available conjugated. Format: E45R30285N-Conjugate. Price: $485 / Size: 100μl.

E45R30285N-FITC$485 / 100μlE45R30285N-Biotin$485 / 100μlE45R30285N-HRP$485 / 100μlE45R30285N-AP$485 / 100μlE45R30285N-AF350$485 / 100μlE45R30285N-AF405M$485 / 100μlE45R30285N-AF488$485 / 100μlE45R30285N-AF514$485 / 100μlE45R30285N-AF532$485 / 100μlE45R30285N-AF555$485 / 100μlE45R30285N-AF568$485 / 100μlE45R30285N-AF405S$485 / 100μlE45R30285N-AF405L$485 / 100μlE45R30285N-AF546$485 / 100μlE45R30285N-AF594$485 / 100μlE45R30285N-AF610$485 / 100μlE45R30285N-AF635$485 / 100μlE45R30285N-AF647$485 / 100μlE45R30285N-AF680$485 / 100μlE45R30285N-AF700$485 / 100μlE45R30285N-AF750$485 / 100μlE45R30285N-AF790$485 / 100μlE45R30285N-APC$485 / 100μlE45R30285N-PE$485 / 100μlE45R30285N-Cy3$485 / 100μlE45R30285N-Cy5$485 / 100μlE45R30285N-Cy5.5$485 / 100μlE45R30285N-Cy7$485 / 100μlE45R30285N-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.

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Phospho-RIPK1-S166 Rabbit pAb | EnoGene Biotech Co. Ltd