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MLLT3 Rabbit pAb
Human
$409/ 100 µl
QuantityTotal: $409
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Cite ID#EN5518127
TypePolyclonal Antibodies
HostRabbit
Positive controlTHP-1, Jurkat, A-549
IsotypeIgG
SummaryChromatin reader component of the super elongation complex (SEC, a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically recognizes and binds acylated histone H3, with a preference for histone H3 that is crotonylated. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr, and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr. Also recognizes and binds histone H3 acetylated and butyrylated at 'Lys-9' (H3K9ac and H3K9bu, respectively, but with lower affinity than crotonylated histone H3. In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones. Recruitment of the SEC complex to crotonylated histones promotes recruitment of DOT1L on active chromatin to deposit histone H3 'Lys-79' methylation (H3K79me. Plays a key role in hematopoietic stem cell (HSC maintenance by preserving, rather than confering, HSC stemness. Acts by binding to the transcription start site of active genes in HSCs and sustaining level of H3K79me2, probably by recruiting DOT1L.
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Price409$
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human MLLT3 (NP_004520.2).
PurificationAffinity purification
Gene ID4300
Storage/StabilityStore at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
DilutionWB 1:500 - 1:2000
All Names
AlternameMLLT3; AF9; YEATS3
Conjugated Antibody
This product is also available conjugated. Format: E45R30092N-Conjugate. Price: $485 / Size: 100μl.
E45R30092N-FITC$485 / 100μlE45R30092N-Biotin$485 / 100μlE45R30092N-HRP$485 / 100μlE45R30092N-AP$485 / 100μlE45R30092N-AF350$485 / 100μlE45R30092N-AF405M$485 / 100μlE45R30092N-AF488$485 / 100μlE45R30092N-AF514$485 / 100μlE45R30092N-AF532$485 / 100μlE45R30092N-AF555$485 / 100μlE45R30092N-AF568$485 / 100μlE45R30092N-AF405S$485 / 100μlE45R30092N-AF405L$485 / 100μlE45R30092N-AF546$485 / 100μlE45R30092N-AF594$485 / 100μlE45R30092N-AF610$485 / 100μlE45R30092N-AF635$485 / 100μlE45R30092N-AF647$485 / 100μlE45R30092N-AF680$485 / 100μlE45R30092N-AF700$485 / 100μlE45R30092N-AF750$485 / 100μlE45R30092N-AF790$485 / 100μlE45R30092N-APC$485 / 100μlE45R30092N-PE$485 / 100μlE45R30092N-Cy3$485 / 100μlE45R30092N-Cy5$485 / 100μlE45R30092N-Cy5.5$485 / 100μlE45R30092N-Cy7$485 / 100μlE45R30092N-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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