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OMA1 Rabbit pAb
Human, Mouse, Rat
$409/ 100 µl
QuantityTotal: $409
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Cite ID#EN5517962
TypePolyclonal Antibodies
HostRabbit
Positive control293T, LO2, K-562
IsotypeIgG
SummaryMetalloprotease that is part of the quality control system in the inner membrane of mitochondria. Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OPA1, UQCC3 and DELE1. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Also acts as a regulator of apoptosis: upon BAK and BAX aggregation, mediates cleavage of OPA1, leading to the remodeling of mitochondrial cristae and allowing the release of cytochrome c from mitochondrial cristae. In depolarized mitochondria, may also act as a backup protease for PINK1 by mediating PINK1 cleavage and promoting its subsequent degradation by the proteasome. May also cleave UQCC3 in response to mitochondrial depolarization. Also acts as an activator of the integrated stress response (ISR: in response to mitochondrial stress, mediates cleavage of DELE1 to generate the processed form of DELE1 (S-DELE1, which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions (By similarity. Binds cardiolipin, possibly regulating its protein turnover (By similarity. Required for the stability of the respiratory supercomplexes (By similarity.
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Price409$
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 360-524 of human OMA1 (NP_660286.1).
PurificationAffinity purification
Gene ID115209
Storage/StabilityStore at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
DilutionWB 1:500 - 1:2000
IF 1:50 - 1:100
IF 1:50 - 1:100
All Names
AlternameOMA1; 2010001O09Rik; DAB1; MPRP-1; MPRP1; YKR087C; ZMPOMA1; peptidase
Conjugated Antibody
This product is also available conjugated. Format: E45R29927N-Conjugate. Price: $485 / Size: 100μl.
E45R29927N-FITC$485 / 100μlE45R29927N-Biotin$485 / 100μlE45R29927N-HRP$485 / 100μlE45R29927N-AP$485 / 100μlE45R29927N-AF350$485 / 100μlE45R29927N-AF405M$485 / 100μlE45R29927N-AF488$485 / 100μlE45R29927N-AF514$485 / 100μlE45R29927N-AF532$485 / 100μlE45R29927N-AF555$485 / 100μlE45R29927N-AF568$485 / 100μlE45R29927N-AF405S$485 / 100μlE45R29927N-AF405L$485 / 100μlE45R29927N-AF546$485 / 100μlE45R29927N-AF594$485 / 100μlE45R29927N-AF610$485 / 100μlE45R29927N-AF635$485 / 100μlE45R29927N-AF647$485 / 100μlE45R29927N-AF680$485 / 100μlE45R29927N-AF700$485 / 100μlE45R29927N-AF750$485 / 100μlE45R29927N-AF790$485 / 100μlE45R29927N-APC$485 / 100μlE45R29927N-PE$485 / 100μlE45R29927N-Cy3$485 / 100μlE45R29927N-Cy5$485 / 100μlE45R29927N-Cy5.5$485 / 100μlE45R29927N-Cy7$485 / 100μlE45R29927N-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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