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cGAS Rabbit pAb
Human, Mouse, Rat
$409/ 100 µl
QuantityTotal: $409
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Cite ID#EN5517885
TypePolyclonal Antibodies
HostRabbit
Positive controlU-87MG, HeLa, Mouse testis, Mouse thymus, Mouse brain, Rat thymus
IsotypeIgG
SummaryNucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:23258413, PubMed:23707061, PubMed:23722159, PubMed:24077100, PubMed:25131990, PubMed:29976794, PubMed:30799039). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28363908, PubMed:28214358). Acts as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production (PubMed:28363908, PubMed:28314590). Preferentially recognizes and binds curved long DNAs (PubMed:30007416). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less cyclic GMP-AMP (cGAMP), allowing a more fine-tuned response to pathogens (PubMed:30007416). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-1, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote TMEM173/STING activation and convey immune response to connecting cells (PubMed:24077100).
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Price409$
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 400-522 of human cGAS (NP_612450.2).
PurificationAffinity purification
Gene ID115004
Storage/StabilityStore at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
DilutionWB 1:500 - 1:2000
IHC 1:50 - 1:200
IHC 1:50 - 1:200
All Names
AlternameMB21D1; C6orf150; cGAS; h-cGAS; CGAS
Conjugated Antibody
This product is also available conjugated. Format: E45R29850N-Conjugate. Price: $485 / Size: 100μl.
E45R29850N-FITC$485 / 100μlE45R29850N-Biotin$485 / 100μlE45R29850N-HRP$485 / 100μlE45R29850N-AP$485 / 100μlE45R29850N-AF350$485 / 100μlE45R29850N-AF405M$485 / 100μlE45R29850N-AF488$485 / 100μlE45R29850N-AF514$485 / 100μlE45R29850N-AF532$485 / 100μlE45R29850N-AF555$485 / 100μlE45R29850N-AF568$485 / 100μlE45R29850N-AF405S$485 / 100μlE45R29850N-AF405L$485 / 100μlE45R29850N-AF546$485 / 100μlE45R29850N-AF594$485 / 100μlE45R29850N-AF610$485 / 100μlE45R29850N-AF635$485 / 100μlE45R29850N-AF647$485 / 100μlE45R29850N-AF680$485 / 100μlE45R29850N-AF700$485 / 100μlE45R29850N-AF750$485 / 100μlE45R29850N-AF790$485 / 100μlE45R29850N-APC$485 / 100μlE45R29850N-PE$485 / 100μlE45R29850N-Cy3$485 / 100μlE45R29850N-Cy5$485 / 100μlE45R29850N-Cy5.5$485 / 100μlE45R29850N-Cy7$485 / 100μlE45R29850N-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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