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MAP3K4 Rabbit pAb
Human, Rat
$409/ 100 µl
QuantityTotal: $409
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Cite ID#EN5517834
TypePolyclonal Antibodies
HostRabbit
Positive controlK-562, Rat brain
IsotypeIgG
SummaryThe central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described.
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Price409$
ImmunogenA synthetic peptide corresponding to a sequence within amino acids 1-100 of human MAP3K4 (NP_005913.2).
PurificationAffinity purification
Gene ID4216
Storage/StabilityStore at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
DilutionWB 1:500 - 1:2000
IHC 1:100 - 1:200
IHC 1:100 - 1:200
All Names
AlternameMAP3K4; MAPKKK4; MEKK 4; MEKK4; MTK1; PRO0412
Conjugated Antibody
This product is also available conjugated. Format: E45R29799N-Conjugate. Price: $485 / Size: 100μl.
E45R29799N-FITC$485 / 100μlE45R29799N-Biotin$485 / 100μlE45R29799N-HRP$485 / 100μlE45R29799N-AP$485 / 100μlE45R29799N-AF350$485 / 100μlE45R29799N-AF405M$485 / 100μlE45R29799N-AF488$485 / 100μlE45R29799N-AF514$485 / 100μlE45R29799N-AF532$485 / 100μlE45R29799N-AF555$485 / 100μlE45R29799N-AF568$485 / 100μlE45R29799N-AF405S$485 / 100μlE45R29799N-AF405L$485 / 100μlE45R29799N-AF546$485 / 100μlE45R29799N-AF594$485 / 100μlE45R29799N-AF610$485 / 100μlE45R29799N-AF635$485 / 100μlE45R29799N-AF647$485 / 100μlE45R29799N-AF680$485 / 100μlE45R29799N-AF700$485 / 100μlE45R29799N-AF750$485 / 100μlE45R29799N-AF790$485 / 100μlE45R29799N-APC$485 / 100μlE45R29799N-PE$485 / 100μlE45R29799N-Cy3$485 / 100μlE45R29799N-Cy5$485 / 100μlE45R29799N-Cy5.5$485 / 100μlE45R29799N-Cy7$485 / 100μlE45R29799N-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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