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CASP1 Rabbit pAb
Mouse, Rat
$409/ 100 µl
QuantityTotal: $409
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Cite ID#EN5517144
TypePolyclonal Antibodies
HostRabbit
Positive controlMouse testis
IsotypeIgG
SummaryThiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B and interleukin 18 (IL18 as well as the pyroptosis inducer Gasdermin-D (GSDMD, into active mature peptides. Plays a key role in cell immunity as an inflammatory response initiator: once activated through formation of an inflammasome complex, it initiates a proinflammatory response through the cleavage of the two inflammatory cytokines IL1B and IL18, releasing the mature cytokines which are involved in a variety of inflammatory processes. Cleaves a tetrapeptide after an Asp residue at position P1. Also initiates pyroptosis, a programmed lytic cell death pathway, through cleavage of GSDMD. In contrast to cleavage of interleukins IL1B and IL1B, recognition and cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT part. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly (By similarity.
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Price409$
ImmunogenRecombinant protein of Mouse CASP1.
PurificationAffinity purification
Gene ID12362
Storage/StabilityStore at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
DilutionWB 1:500 - 1:2000
IF 1:50 - 1:200
IF 1:50 - 1:200
All Names
AlternameIC; ICE; Il1; Casp; Il1bc
Conjugated Antibody
This product is also available conjugated. Format: E45R29108N-Conjugate. Price: $485 / Size: 100μl.
E45R29108N-FITC$485 / 100μlE45R29108N-Biotin$485 / 100μlE45R29108N-HRP$485 / 100μlE45R29108N-AP$485 / 100μlE45R29108N-AF350$485 / 100μlE45R29108N-AF405M$485 / 100μlE45R29108N-AF488$485 / 100μlE45R29108N-AF514$485 / 100μlE45R29108N-AF532$485 / 100μlE45R29108N-AF555$485 / 100μlE45R29108N-AF568$485 / 100μlE45R29108N-AF405S$485 / 100μlE45R29108N-AF405L$485 / 100μlE45R29108N-AF546$485 / 100μlE45R29108N-AF594$485 / 100μlE45R29108N-AF610$485 / 100μlE45R29108N-AF635$485 / 100μlE45R29108N-AF647$485 / 100μlE45R29108N-AF680$485 / 100μlE45R29108N-AF700$485 / 100μlE45R29108N-AF750$485 / 100μlE45R29108N-AF790$485 / 100μlE45R29108N-APC$485 / 100μlE45R29108N-PE$485 / 100μlE45R29108N-Cy3$485 / 100μlE45R29108N-Cy5$485 / 100μlE45R29108N-Cy5.5$485 / 100μlE45R29108N-Cy7$485 / 100μlE45R29108N-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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