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TET3 Rabbit pAb
Human, Mouse, Rat
$409/ 100 µl
QuantityTotal: $409
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Cite ID#EN5517131
TypePolyclonal Antibodies
HostRabbit
Positive control293T
IsotypeIgG
SummaryDioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC into 5-hydroxymethylcytosine (5hmC and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC, and conversion of 5fC to 5-carboxylcytosine (5caC. Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG dinucleotides over CpH (H=A, T, and C, hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity.
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Price409$
ImmunogenRecombinant protein of Mouse TET3.
PurificationAffinity purification
Gene ID194388
Storage/StabilityStore at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
DilutionWB 1:500 - 1:2000
All Names
AlternameBC037432; B430006D22Rik; D230004J03Rik
Conjugated Antibody
This product is also available conjugated. Format: E45R29095N-Conjugate. Price: $485 / Size: 100μl.
E45R29095N-FITC$485 / 100μlE45R29095N-Biotin$485 / 100μlE45R29095N-HRP$485 / 100μlE45R29095N-AP$485 / 100μlE45R29095N-AF350$485 / 100μlE45R29095N-AF405M$485 / 100μlE45R29095N-AF488$485 / 100μlE45R29095N-AF514$485 / 100μlE45R29095N-AF532$485 / 100μlE45R29095N-AF555$485 / 100μlE45R29095N-AF568$485 / 100μlE45R29095N-AF405S$485 / 100μlE45R29095N-AF405L$485 / 100μlE45R29095N-AF546$485 / 100μlE45R29095N-AF594$485 / 100μlE45R29095N-AF610$485 / 100μlE45R29095N-AF635$485 / 100μlE45R29095N-AF647$485 / 100μlE45R29095N-AF680$485 / 100μlE45R29095N-AF700$485 / 100μlE45R29095N-AF750$485 / 100μlE45R29095N-AF790$485 / 100μlE45R29095N-APC$485 / 100μlE45R29095N-PE$485 / 100μlE45R29095N-Cy3$485 / 100μlE45R29095N-Cy5$485 / 100μlE45R29095N-Cy5.5$485 / 100μlE45R29095N-Cy7$485 / 100μlE45R29095N-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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